Hormonal influence on experimental infections by a toxic shock strain of Staphylococcus aureus.

نویسندگان

  • G K Best
  • T O Abney
  • J M Kling
  • J J Kirkland
  • D F Scott
چکیده

Subcutaneous infection chambers in rabbits were infected with a strain of Staphylococcus aureus isolated from a patient with toxic shock syndrome. Estrogens (mestranol and 17-beta-estradiol) protected male rabbits and prolonged survival. Neither androgens (testosterone and dihydrotestosterone) nor progesterone affected the susceptibility of intact or ovarihysterectomized female rabbits.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Identification of Toxic Shock Syndrome Toxin-1 (TSST-1) gene in Staphylococcus aureus isolated from bovine mastitis milk

Staphylococcus aureus is a major causative pathogen of clinical and subclinical mastitis of dairy domestic ruminants. This agent produces a variety of extracellular toxins and virulence factors including Toxic Shock Syndrome Toxin-1 (TSST-1) which is the major cause of Toxic Shock Syndrome (TSS). In this study 58 S. aureus isolates obtained from 9 dairy herds in East and West Azerbaijan provinc...

متن کامل

Production of toxic shock syndrome-like illness in rabbits by Staphylococcus aureus D4508: association with enterotoxin A.

Staphylococcus aureus D4508, obtained from a patient with nonmenstrual toxic shock syndrome (TSS), produced enterotoxin A while not making other known enterotoxins or TSS toxin 1. Concentrated culture fluids of the organism, administered subcutaneously in miniosmotic pumps, induced TSS-like symptoms (four of six animals succumbed). Identical culture fluids pretreated with anti-enterotoxin A ser...

متن کامل

The Impact of Staphylococcus aureus-Associated Molecular Patterns on Staphylococcal Superantigen-Induced Toxic Shock Syndrome and Pneumonia

Staphylococcus aureus is capable of causing a spectrum of human illnesses. During serious S. aureus infections, the staphylococcal pathogen-associated molecular patterns (PAMPs) such as peptidoglycan, lipoteichoic acid, and lipoproteins and even intact S. aureus, are believed to act in conjunction with the staphylococcal superantigens (SSAg) to activate the innate and adaptive immune system, re...

متن کامل

فراوانی ژن‌های tst، entBو entC در میان نمونه‌های بالینی استافیلوکوک اورئوس جدا شده ازبیماران بستری دربیمارستان‌های آموزشی قزوین

Abstract Background: Staphylococcus aureus is one of the most common infectious bacterial pathogens. TSST-1 and enterotoxins are the major virulence factors of this organism which are superantigens and cause the toxic shock syndrome. The toxin-encoding genes are located on pathogenicity islands with the ability to move to non-toxigenic strains. This study was done to determine the frequency of ...

متن کامل

Are SARS Superspreaders Cloud Adults?

1. Furukawa Y, Segawa Y, Masuda K, Takahashi M, Ootsuka A, Hirai K, et al. Clinical experience of 3 cases of toxic shock syndrome caused by methicillin cephem-resistant Staphylococcus aureus (MRSA). Kansenshogaku Zasshi. 1986; 60:1147–53. 2. Meyer RD, Monday SR, Bohach GA, Schlievert PM. Prolonged course of toxic shock syndrome associated with methicillin-resistant Staphylococcus aureus enterot...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Infection and immunity

دوره 52 1  شماره 

صفحات  -

تاریخ انتشار 1986